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https://pubmed.ncbi.nlm.nih.gov/30775997/ Background: Astrocytes produce and store the energy reserve glycogen. However, abnormal large glycogen units accumulate if the production or degradation of glycogen is disturbed, a finding often seen in patients with Alzheimer's disease (AD). We have shown increased activity of glycogen degrading α-amylase in AD patients and α-amylase positive glial cells adjacent to AD characteristic amyloid-β (Aβ) plaques. https://www.sciencedirect.com/science/article/pii/S0014579310000918 Abstract Amyloid deposits, which accumulate in numerous diseases, are the final stage of multi-step protein conformational-conversion and oligomerization processes. The underlying molecular mechanisms are not fully understood, and particularly little is known about the reverse reaction. Here we show that phosphoglycerate kinase amyloid fibrils can be converted back into native protein. We achieved recovery with 60% efficiency, which is comparable to the success rate of the unfolding-refolding studies, and the recovered enzyme was folded, stable and fully active. The key intermediate stages in the recovery process are fibril disassembly and unfolding followed by spontaneous protein folding. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4482321/ Background & Aim Alpha-amylase in both blood and saliva has been used as a diagnostic parameter. While studies examining alpha-amylase activity in saliva have shown that it is sensitive to physiological and psychological challenge of the adrenergic system, no challenge studies have attempted to elucidate the role of the adrenergic system in alpha-amylase activity in blood. We set out to examine the impact of psychological and pharmacological challenge on alpha-amylase in blood in two separate studies. - this one is very interesting because until my late 30s my body responded intensively with adrenergic stimulation to heat me up and burn down my blood sugar - it is talking about yohimbe https://chasdomundo.pt/en/pau-de-cabinda-bark-10-sachets?category_rewrite=pau-de-cabinda-bark-10-sachets i can get yohimbe if yohimbe increases release of alpha amylase then this will also accelerate the decomposition of amyloid plaques

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